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KMID : 0361020210640120906
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Korean Journal of Otolaryngology - Head and Neck Surgery
2021 Volume.64 No. 12 p.906 ~ p.913
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Comparative Analysis About Clinical Manifestation and Prognostic Factors of Thyroid Follicular and Hurthle Cell Carcinoma
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Kim Jung-Jun
Kim Brian
Choi Ik-Joon
Lee Byeong-Cheol
Ahn Jung-Min
Kong Joon-Seog
Lee Myung-Chul
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Abstract
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Background and Objectives : Follicular thyroid carcinoma (FTC) is the second commonthyroid cancer which comprises about 10% of differentiated thyroid carcinoma. Hurthle cellcarcinoma (HCC) is a relatively rare disease that has been classified as a subtype of FTC.
However, there have been insufficient reports about these two similar thyroid cancers in SouthKorea due to low incidences. This study aims to present clinical features and evaluate prognosticfactors of FTC and HCC.
Subjects and Method : We reviewed data of 189 FTC and 12 HCC patients who underwentsurgery in our center from January 2000 to December 2020. Variables such as clinical characteristics,surgical method, pathologic result, post-operative treatment, survival rate and prognosticfactors were included in our study.
Results : As for age, 67.2% of patients in FTC group and 33.3% of patients in HCC groupwere older than 55 years-old (p=0.017). The average tumor sizes of FTC and HCC were 2.98and 3.1 cm, respectively. The 10-year overall survival rates of FTC and HCC were 96.5% and100%, respectively. The 10-year disease free survival rates of FTC and HCC were 89.1% and91.7%, respectively. Subclassification (widely invasive: p=0.036) and initial distant metastasis(p<0.001) were significant prognostic factors in FTC.
Conclusion : This study will be helpful for diagnosis and treatment of FTC and HCC, whichare relatively rare.
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KEYWORD
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Carcinoma, Follicular carcinoma, Hurthle cell, Prognosis, Thyroid
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